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Product Details
PD2A3-301AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A3 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line) (PubMed:24705027).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 2; cGMP-stimulated phosphodiesterase 4; CGS-PDE; cGSPDE; cyclic GMP stimulated phosphodiesterase; Cyclic GMP-stimulated phosphodiesterase; PDE2A; phosphodiesterase 2A, cGMP-stimulated
Gene Aliases: CGS-PDE; cGSPDE; Pde2; PDE2A; PDE2A1; Pde2a2; PED2A4
UniProt ID: (Human) O00408, (Rat) Q01062, (Mouse) Q922S4
Entrez Gene ID: (Human) 5138, (Rat) 81743, (Mouse) 207728
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
calcium channel activity
protein binding
drug binding
cAMP binding
cGMP binding
TPR domain binding
protein homodimerization activity
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
GAF domain binding
nucleotide binding
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
negative regulation of transcription from RNA polymerase II promoter
cAMP catabolic process
protein targeting to mitochondrion
metabolic process
cAMP-mediated signaling
cGMP-mediated signaling
negative regulation of cAMP biosynthetic process
negative regulation of protein import into nucleus, translocation
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
calcium ion transmembrane transport
cellular response to mechanical stimulus
cellular response to cGMP
cellular response to transforming growth factor beta stimulus
positive regulation of gene expression
monocyte differentiation
regulation of cGMP metabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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