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PDE4B Antibody (PA5-29833) in WB
Western Blot analysis of PDE4B was performed by separating 50 µg of Rat tissue extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a PDE4B Polyclonal Antibody (Product # PA5-29833) at a dilution of 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
PA5-29833
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 491 and 736 of Human PDE4B
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547307
产品详细信息
Recommended positive controls: A549, H1299, U87-MG, SK-N-SH, rat brain.
Predicted reactivity: Mouse (98%), Rat (97%), Xenopus laevis (89%), Pig (98%), Chicken (93%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3',5'-cyclic AMP phosphodiesterase; 3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase 4B; DKFZp686F2182; DPDE4; dunce-like phosphodiesterase E4; MGC126529; MGC93193; OTTHUMP00000046896; PDE32; Phosphodiesterase 4B cAMP-specific (dunce; Phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); RP5-876C12.1
基因别名: DPDE4; PDE4/IVb; PDE4B; Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDEIVB
UniProt ID: (Human) Q07343, (Rat) P14646
Entrez Gene ID: (Human) 5142, (Rat) 24626
neutrophil homeostasis
cAMP catabolic process
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
cellular response to drug
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
regulation of cardiac muscle cell contraction
regulation of high voltage-gated calcium channel activity
negative regulation of relaxation of cardiac muscle
smooth muscle contraction
signal transduction
metabolic process
