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产品信息
PA1-31136
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C-terminal cyclic peptide unique to all PDE4D subtypes variants.
偶联物
形式
Liquid
浓度
0.78 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris glycine, pH 7.4-4.9, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2161086
产品详细信息
PA1-31136 detects PDE4D from mouse, human, rat samples.
靶标信息
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136
基因别名: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1
UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
drug binding
enzyme binding
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
metal ion binding
ATPase binding
scaffold protein binding
cyclic-nucleotide phosphodiesterase activity
SH3 domain binding
protein domain specific binding
ubiquitin protein ligase binding
phosphoric diester hydrolase activity
hydrolase activity
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
memory
regulation of G-protein coupled receptor protein signaling pathway
regulation of receptor activity
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
cellular protein complex assembly
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
negative regulation of relaxation of cardiac muscle
signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
cAMP-mediated signaling
regulation of cAMP metabolic process
