Invitrogen

PDE4D Polyclonal Antibody

PDE4D Antibody in Immunocytochemistry (ICC/IF)

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PDE4D Antibody (PA5-21590) in ICC/IF

Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed A431, using PDE4D antibody (Product # PA5-21590) (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with (Product # MA1-25054) (Red) at 1:500.

PDE4D Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-21590

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

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免疫沉淀 (IP)

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to a region within amino acids 746 and 809 of PDE4D (Uniprot ID#Q08499)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_11153603

产品详细信息

Recommended positive controls: A431, HeLa.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.

JCI insight

Jeong MH,Urquhart G,Lewis C,Chi Z,Jewell JL

PA5-21590 was used in Immunoprecipitation to identify PDE4D as an important activator of mTORC1 and suggest that targeting PDE4 with FDA-approved inhibitors may be beneficial for the treatment of human diseases with hyperactivated mTORC1 signaling.

Mon Jul 10 00:00:00 UTC 2023

Inhibition of phosphodiesterase 4D suppresses mTORC1 signaling and pancreatic cancer growth.

JCI insight

Jeong MH,Urquhart G,Lewis C,Chi Z,Jewell JL

Mon Jul 10 00:00:00 UTC 2023

Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction.

Human mutation

Abou Ziki MD,Bhat N,Neogi A,Driscoll TP,Ugwu N,Liu Y,Smith E,Abboud JM,Chouairi S,Schwartz MA,Akar JG,Mani A

PA5-21590 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to evaluate atrial fibrillation caused by PDE4DIP and DES mutations.

Fri Oct 01 00:00:00 UTC 2021

生物信息学

蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; DKFZp686M11213; DPDE3; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136

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基因别名: ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1

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UniProt ID: (Human) Q08499

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Entrez Gene ID: (Human) 5144

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功能