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PDE8A Antibody (PD8A-112AP) in WB
WB of PD8A-112AP with non-reduced and heated samples listed below. 1:500 antibody dilution in DiluOBuffer (FGI-1963) at room temperature for 2 hours. Lane 1: SDS-solubilied PDE8 cell cytosol Lane 2: SDS-solubilized treated-PDE8 cell cytosol Lane 3: SDS-solubilized PDE8 cell membrane.
产品信息
PD8A-112AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic cyclic peptide from mid-region common to all PDE8A variants.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction. PDEs comprise a large superfamily of enzymes divided into 10 families. Different PDEs can be distinguished by their structure, tissue expression, localization, substrate specificity, regulation, and sensitivity to PDE inhibitors. Diversity in structure and specificity of function make PDEs promising targets for the pharmacotherapy of diseases modulated by cyclic nucleotide signaling (Hetman et al., 2000).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP-specific cyclic nucleotide phosphodiesterase 8A; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; FLJ16150; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; MmPDE8
基因别名: AI551852; HsT19550; Pde8; PDE8A; RNPDE8A
UniProt ID: (Human) O60658, (Mouse) O88502
Entrez Gene ID: (Human) 5151, (Mouse) 18584, (Rat) 308776
