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产品信息
PD8B-201AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic cyclic peptide common to all PDE8B variants.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3',5' cyclic nucleotide phosphodiesterase 8B; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; Cell proliferation-inducing gene 22 protein; FLJ11212; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B
基因别名: ADSD; B230331L10Rik; C030047E14Rik; PDE8B; PIG22; PPNAD3; RNPDE8B
UniProt ID: (Human) O95263
Entrez Gene ID: (Human) 8622, (Rat) 309962, (Mouse) 218461
cAMP catabolic process
signal transduction
cyclic nucleotide metabolic process
negative regulation of insulin secretion
phosphorelay signal transduction system
behavioral fear response
metabolic process
visual learning
operant conditioning
neuromuscular process controlling balance
negative regulation of steroid hormone biosynthetic process
