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产品信息
MA5-51346
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8E0M8
抗原
A synthetic peptide corresponding to a sequence within amino acids 142-241 of human PDGFB (NP_002599.1).
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_3092923
产品详细信息
Immunogen sequence: RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVTR SPGGSQEQRA KTPQTRVTIR TVRVRRPPKG KHRKFKHTHD KTALKETLGA
靶标信息
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
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生物信息学
蛋白别名: c-sis; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor subunit B; Proto-oncogene c-Sis
基因别名: PDGF-B; Pdgfb; Sis
UniProt ID: (Mouse) P31240
Entrez Gene ID: (Mouse) 18591
receptor binding
platelet-derived growth factor receptor binding
collagen binding
growth factor activity
superoxide-generating NADPH oxidase activator activity
chemoattractant activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
platelet-derived growth factor binding
growth factor
embryonic placenta development
positive regulation of endothelial cell proliferation
monocyte chemotaxis
positive regulation of glomerular filtration
protein phosphorylation
substrate-dependent cell migration
multicellular organism development
synapse assembly
heart development
positive regulation of cell proliferation
response to wounding
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
neuron remodeling
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
glial cell development
cell projection assembly
actin cytoskeleton organization
positive regulation of cell migration
negative regulation of cell migration
positive regulation of protein autophosphorylation
negative regulation of protein binding
activation of protein kinase activity
activation of protein kinase B activity
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
paracrine signaling
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
eye photoreceptor cell development
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of DNA replication
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
negative regulation of vasodilation
positive regulation of mitotic cell cycle, embryonic
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of chemotaxis
positive regulation of cell division
retina development in camera-type eye
cell chemotaxis
branching involved in salivary gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
cardiac vascular smooth muscle cell differentiation
positive regulation of protein tyrosine kinase activity
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to mycophenolic acid
positive regulation of glomerular mesangial cell proliferation
metanephric glomerular mesangial cell development
metanephric glomerular mesangial cell proliferation involved in metanephros development
reactive oxygen species metabolic process
positive regulation of calcium ion import
positive regulation of hyaluronan biosynthetic process
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
positive regulation of metanephric mesenchymal cell migration
