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Product Details
PA5-27989
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 78 and 359 of Human Pyruvate Dehydrogenase E1 beta subunit
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545465
Product Specific Information
Recommended positive controls: A549, H1299, HCT116, mouse heart, rat heart.
Predicted reactivity: Mouse (94%), Rat (94%), Zebrafish (85%), Xenopus laevis (84%), Pig (94%), Chicken (85%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PDHB (Pyruvate dehydrogenase E1 component subunit beta, mitochondrial) is also named as PHE1B. The enzyme, which is found in mitochondria, is one of the component enzymes of the pyruvate dehydrogenase multienzyme complex (PDH). It catalyzes the first reaction of an oxidative decarboxylation sequence converting pyruvate to acetyl-CoA and CO(2). Defects in PDHB are the cause of pyruvate dehydrogenase E1-beta deficiency (PDHBD).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PDHE1-B; Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; pyruvate dehydrogenase, E1 beta polypeptide
Gene Aliases: 2610103L06Rik; AL024199; C81408; PDHB; PDHBD; PDHE1-B; PHE1B
UniProt ID: (Human) P11177, (Rat) P49432, (Mouse) Q9D051
Entrez Gene ID: (Human) 5162, (Rat) 289950, (Mouse) 68263
glucose metabolic process
acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
tricarboxylic acid cycle
regulation of acetyl-CoA biosynthetic process from pyruvate
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate
carbohydrate metabolic process
metabolic process
oxidation-reduction process
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