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PEAR1 Antibody (PA5-112645) in ICC/IF
Immunocytochemichal analysis of PEAR1 in U251 cells using a Polyclonal antibody (Product # PA5-112645) at a dilution of 1:133. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were also counter-stained with DAPI.
产品信息
PA5-112645
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Platelet endothelial aggregation receptor 1 protein (932-1037AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867380
靶标信息
Platelet endothelial aggregation receptor 1 (PEAR1) is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation. Upon platelet aggregation stimulated by physiological agonists, PEAR1 becomes tyrosine- and serine-phosphorylated; the tyrosine phosphorylation can be inhibited by eptifibatide, an aIIbbeta3 antagonist that also inhibits platelet aggregation. Recent studies have indicated that genetic variations in PEAR1, may be associated with enhanced agonist-induced platelet aggregation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPEAR1; Jagged and Delta protein; Jedi; mPEAR1; Multiple EGF-like domains protein 12; multiple EGF-like-domains 12; Multiple epidermal growth factor-like domains protein 12; Platelet endothelial aggregation receptor 1; Protein Jedi; RP11-107D16.3
基因别名: 3110045G13Rik; JEDI; Jedi-1; MEGF12; PEAR1; RGD1305653
UniProt ID: (Human) Q5VY43, (Mouse) Q8VIK5
Entrez Gene ID: (Human) 375033, (Mouse) 73182, (Rat) 295293
