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产品信息
MA5-34830
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE41-28
抗原
Recombinant protein within Human PEN2 aa 1-101
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848738
产品详细信息
Positive Control: Mouse spleen tissue, rat cerebellum tissue, human tonsil tissue, human lung cancer tissue, human kidney tissue, mouse testis tissue, A549, SH-SY-5Y.
靶标信息
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; Presenilin enhancer protein 2
基因别名: MDS033; MSTP064; PEN-2; PEN2; PSENEN
UniProt ID: (Human) Q9NZ42
Entrez Gene ID: (Human) 55851
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
protein processing
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
positive regulation of apoptotic process
positive regulation of catalytic activity
ephrin receptor signaling pathway
