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产品信息
PA5-120620
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 867-1116 of human PERK (NP_004827.4).
偶联物
形式
Liquid
浓度
0.99 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914192
产品详细信息
Positive test controls include: Mouse thymus. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type I membrane protein.
Immunogen sequence: LTKNTTEKLQ PSSPKVYLYI QMQLCRKENL KDWMNGRCTI EERERSVCLH IFLQIAEAVE FLHSKGLMHR DLKPSNIFFT MDDVVKVGDF GLVTAMDQDE EEQTVLTPMP AYARHTGQVG TKLYMSPEQI HGNSYSHKVD IFSLGLILFE LLYPFSTQME RVRTLTDVRN LKFPPLFTQK YPCEYVMVQD MLSPSPMERP EAINIIENAV FEDLDFPGKT VLRQRSRSLS SSGTKHSRQS NNSHSPLPSN
靶标信息
EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase
基因别名: AI427929; EIF2AK3; PEK; PERK; WRS
UniProt ID: (Human) Q9NZJ5, (Rat) Q9Z1Z1, (Mouse) Q9Z2B5
Entrez Gene ID: (Human) 9451, (Rat) 29702, (Mouse) 13666
protein kinase activity
protein serine/threonine kinase activity
eukaryotic translation initiation factor 2alpha kinase activity
protein binding
ATP binding
enzyme binding
protein phosphatase binding
identical protein binding
protein homodimerization activity
Hsp90 protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
eukaryotic initiation factor eIF2 binding
non-receptor serine/threonine protein kinase
skeletal system development
ossification
angiogenesis
chondrocyte development
protein phosphorylation
activation of cysteine-type endopeptidase activity involved in apoptotic process
ER overload response
endoplasmic reticulum organization
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
regulation of translational initiation by eIF2 alpha phosphorylation
negative regulation of translation
peptidyl-serine phosphorylation
calcium-mediated signaling
insulin secretion
bone mineralization
endoplasmic reticulum unfolded protein response
endocrine pancreas development
negative regulation of myelination
negative regulation of translational initiation in response to stress
cellular response to amino acid starvation
response to endoplasmic reticulum stress
eiF2alpha phosphorylation in response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
cellular response to glucose starvation
positive regulation of transcription from RNA polymerase I promoter
protein autophosphorylation
insulin-like growth factor receptor signaling pathway
protein homooligomerization
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
cellular response to cold
positive regulation of protein localization to nucleus
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
response to manganese-induced endoplasmic reticulum stress
translation
lactation
positive regulation of signal transduction
negative regulation of gene expression
regulation of fatty acid metabolic process
pancreas development
negative regulation of translation in response to stress
positive regulation of protein binding
SREBP signaling pathway
negative regulation of apoptotic process
fat cell differentiation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of translation
response to unfolded protein
phosphorylation
negative regulation of translation in response to endoplasmic reticulum stress
positive regulation of glutathione biosynthetic process
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
