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PFKFB3 Antibody (A304-248A) in IP
Detection of human PFKFB3 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 to 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-PFKFB3 antibody (Product # A304-248A) (lot 1) used for IP at 6 µg per reaction. PFKFB3 was also immunoprecipitated by rabbit anti-PFKFB3 antibody A304-249A. For blotting immunoprecipitated PFKFB3, A304-249A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
产品信息
A304-248A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 425 to 475 of human 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Bovine and Orangutan
靶标信息
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 6-biphosphatase 3; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Fructose-2; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; PFK/FBPase 3; Renal carcinoma antigen NY-REN-56; RP11-298K24.3
基因别名: iPFK-2; IPFK2; PFK2; PFKFB3
UniProt ID: (Human) Q16875
Entrez Gene ID: (Human) 5209
