Product References
The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase.
PLoS genetics
Knighton LE,Omkar S,Truman AW
Published figure using PGK1 polyclonal antibody (Product # PA5-28612) in Western Blot
Fri Apr 01 00:00:00 UTC 2022
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.
Nature communications
Sharma S,Yang J,Grudzien-Nogalska E,Shivas J,Kwan KY,Kiledjian M
PA5-28612 was used in Western Blot to uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the deNADding activity of Xrn1 fulfilling a central role.
Wed Feb 16 00:00:00 UTC 2022
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.
Nature communications
Sharma S,Yang J,Grudzien-Nogalska E,Shivas J,Kwan KY,Kiledjian M
PA5-28612 was used in Western Blot to uncover a contribution of mitochondrial NAD-capped RNAs in overall NAD regulation with the deNADding activity of Xrn1 fulfilling a central role.
Wed Feb 16 00:00:00 UTC 2022
Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis.
Molecular cell
He D,Feng H,Sundberg B,Yang J,Powers J,Christian AH,Wilkinson JE,Monnin C,Avizonis D,Thomas CJ,Friedman RA,Kluger MD,Hollingsworth MA,Grandgenett PM,Klute KA,Toste FD,Chang CJ,Chio IIC
PA5-28612 was used in Western Blot to demonstrate that methionine residues can act as reversible redox switches governing distinct signaling outcomes and that the MSRA-PKM2 axis serves as a regulatory nexus between redox biology and cancer metabolism to control tumor metastasis.
Thu Aug 18 00:00:00 UTC 2022
The Smk1 MAPK and Its Activator, Ssp2, Are Required for Late Prospore Membrane Development in Sporulating Saccharomyces cerevisiae.
Journal of fungi (Basel, Switzerland)
Durant M,Roesner JM,Mucelli X,Slubowski CJ,Klee E,Seitz BC,Wallis Z,Huang LS
PA5-28612 was used in Western Blotting to find that the Smk1 MAP kinase, along with its activator Ssp2, transiently localizes with the LEP during late meiosis II.
Thu Jan 14 00:00:00 UTC 2021
The Smk1 MAPK and Its Activator, Ssp2, Are Required for Late Prospore Membrane Development in Sporulating Saccharomyces cerevisiae.
Journal of fungi (Basel, Switzerland)
Durant M,Roesner JM,Mucelli X,Slubowski CJ,Klee E,Seitz BC,Wallis Z,Huang LS
PA5-28612 was used in Western Blotting to find that the Smk1 MAP kinase, along with its activator Ssp2, transiently localizes with the LEP during late meiosis II.
Thu Jan 14 00:00:00 UTC 2021
Cex1 is a component of the COPI intracellular trafficking machinery.
Biology open
Enkler L,Rinaldi B,de Craene JO,Hammann P,Nureki O,Senger B,Friant S,Becker HD
Published figure using PGK1 polyclonal antibody (Product # PA5-28612) in Western Blot
Mon Mar 22 00:00:00 UTC 2021
Epigenetic CRISPR Screens Identify Npm1 as a Therapeutic Vulnerability in Non-Small Cell Lung Cancer.
Cancer research
Li F,Ng WL,Luster TA,Hu H,Sviderskiy VO,Dowling CM,Hollinshead KER,Zouitine P,Zhang H,Huang Q,Ranieri M,Wang W,Fang Z,Chen T,Deng J,Zhao K,So HC,Khodadadi-Jamayran A,Xu M,Karatza A,Pyon V,Li S,Pan Y,Labbe K,Almonte C,Poirier JT,Miller G,Possemato R,Qi J,Wong KK
PA5-28612 was used in Western Blotting to support NPM1 as a therapeutic vulnerability in NSCLC. SIGNIFICANCE: Epigenome-wide CRISPR knockout screens identify NPM1 as a novel metabolic vulnerability and demonstrate that targeting NPM1 is a new therapeutic opportunity for patients with NSCLC.
Tue Sep 01 00:00:00 UTC 2020
Mitochondrial-nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites.
Journal of cell science
Martinez-Guzman O,Willoughby MM,Saini A,Dietz JV,Bohovych I,Medlock AE,Khalimonchuk O,Reddi AR
PA5-28612 was used in Western Blotting to indicate that there are parallel pathways for the distribution of bioavailable heme.
Wed May 20 00:00:00 UTC 2020
Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection.
Molecules (Basel, Switzerland)
Li F,Khanom W,Sun X,Paemanee A,Roytrakul S,Wang D,Smith DR,Zhou GC
PA5-28612 was used in Western Blotting to suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.
Fri Oct 30 00:00:00 UTC 2020
Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection.
Molecules (Basel, Switzerland)
Li F,Khanom W,Sun X,Paemanee A,Roytrakul S,Wang D,Smith DR,Zhou GC
PA5-28612 was used in Western Blotting to suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.
Fri Oct 30 00:00:00 UTC 2020
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
Life science alliance
Fan J,Jin H,Koch BA,Yu HG
PA5-28612 was used in Western Blotting to study the interaction between KASH-like proteins Csm4 and Mps3 and the influence of SUN domain protein Mps3 on this pair.
Tue Dec 01 00:00:00 UTC 2020
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
Life science alliance
Fan J,Jin H,Koch BA,Yu HG
PA5-28612 was used in Western Blotting to study the interaction between KASH-like proteins Csm4 and Mps3 and the influence of SUN domain protein Mps3 on this pair.
Tue Dec 01 00:00:00 UTC 2020
Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
Life science alliance
Fan J,Jin H,Koch BA,Yu HG
PA5-28612 was used in Western Blotting to study the interaction between KASH-like proteins Csm4 and Mps3 and the influence of SUN domain protein Mps3 on this pair.
Tue Dec 01 00:00:00 UTC 2020
The anaphase-promoting complex regulates the degradation of the inner nuclear membrane protein Mps3.
The Journal of cell biology
Koch BA,Jin H,Tomko RJ,Yu HG
Published figure using PGK1 polyclonal antibody (Product # PA5-28612) in Western Blot
Mon Mar 04 00:00:00 UTC 2019
Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control.
Nature communications
Winz ML,Peil L,Turowski TW,Rappsilber J,Tollervey D
PA5-28612 was used in Western Blotting to demonstrate a ribosome-associated quality control molecular mechanism, in which Hel2 associates with ribosomal subunits and scans ribosome-mRNA complexes.
Mon Feb 04 00:00:00 UTC 2019
Complex ATP7B mutation patterns in Wilson disease and evaluation of a yeast model for functional analysis of variants.
Human mutation
Li X,Zhang W,Zhou D,Lv T,Xu A,Wang H,Zhao X,Zhang B,Li Y,Jia S,Wang Y,Wang X,Wu Z,Duan W,Wang Q,Nan Y,Shang J,Jiang W,Chen Y,Zheng S,Liu M,Sun L,You H,Jia J,Ou X,Huang J
PA5-28612 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Proximity Ligation Assay, Western Blot to reveal the complex ATP7B mutation patterns in WD patients and the applicability of a yeast model system to the evaluation of the functional consequences of ATP7B variants, which is essential for WD cases that are difficult to interpret.
Wed May 01 00:00:00 UTC 2019
Extra-mitochondrial Cu/Zn superoxide dismutase (Sod1) is dispensable for protection against oxidative stress but mediates peroxide signaling in Saccharomyces cerevisiae.
Redox biology
Montllor-Albalate C,Colin AE,Chandrasekharan B,Bolaji N,Andersen JL,Wayne Outten F,Reddi AR
PA5-28612 was used in Western Blotting to show that the vast majority of Sod1 in yeast is utilised for peroxide-mediated signalling rather than superoxide scavenging.
Fri Feb 01 00:00:00 UTC 2019
Nuclear RNA Decay Pathways Aid Rapid Remodeling of Gene Expression in Yeast.
Molecular cell
Bresson S,Tuck A,Staneva D,Tollervey D
PA528612 was used in western blot to examine the role of nuclear surveillance in reprogramming gene expression in yeast
Thu Mar 02 00:00:00 UTC 2017
Cost-effective and rapid lysis of Saccharomyces cerevisiae cells for quantitative western blot analysis of proteins, including phosphorylated eIF2α.
Yeast (Chichester, England)
Lee SJ,Ramesh R,de Boor V,Gebler JM,Silva RC,Sattlegger E
Published figure using PGK1 polyclonal antibody (Product # PA5-28612) in Western Blot
Fri Sep 01 00:00:00 UTC 2017
Cleavage of the SUN-domain protein Mps3 at its N-terminus regulates centrosome disjunction in budding yeast meiosis.
PLoS genetics
Li P,Jin H,Koch BA,Abblett RL,Han X,Yates JR,Yu HG
Published figure using PGK1 polyclonal antibody (Product # PA5-28612) in Western Blot
Thu Jun 01 00:00:00 UTC 2017
The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly.
The Journal of biological chemistry
Taylor NG,Swenson S,Harris NJ,Germany EM,Fox JL,Khalimonchuk O
PA5-28612 was used in western blot to propose that Pet117 mediates coupling of heme a synthesis to the cytochrome c oxidase assembly process
Fri Feb 03 00:00:00 UTC 2017
The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly.
The Journal of biological chemistry
Taylor NG,Swenson S,Harris NJ,Germany EM,Fox JL,Khalimonchuk O
PA5-28612 was used in western blot to propose that Pet117 mediates coupling of heme a synthesis to the cytochrome c oxidase assembly process
Fri Feb 03 00:00:00 UTC 2017
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.
Proceedings of the National Academy of Sciences of the United States of America
Truttmann MC,Zheng X,Hanke L,Damon JR,Grootveld M,Krakowiak J,Pincus D,Ploegh HL
PA5-28612 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Proximity Ligation Assay, Western Blot to suggest a mode of Hsp70 inactivation by AMPylation and point toward a role for protein AMPylation in the regulation of cellular protein homeostasis beyond the endoplasmic reticulum.
Tue Jan 10 00:00:00 UTC 2017
