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Product Details
PA5-107212
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal region of Human PGLYRP3
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.4, with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2817928
Product Specific Information
Sequence homology: Cow: 93%; Dog: 79%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 79%; Rat: 100%
Target Information
Primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1, 2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-1a mRNA is highly expressed in esophagus, tonsils and thymus and to lesser extent in the stomach, rectum, and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC149197; Peptidoglycan recognition protein 3; peptidoglycan recognition protein I alpha; Peptidoglycan recognition protein I-alpha; Peptidoglycan recognition protein intermediate alpha; PGLYRPIalpha
Gene Aliases: PGLYRP3; PGLYRPIalpha; PGRP-Ialpha; PGRPIA
UniProt ID: (Human) Q96LB9
Entrez Gene ID: (Human) 114771
pattern recognition receptor signaling pathway
peptidoglycan catabolic process
detection of bacterium
negative regulation of interferon-gamma production
negative regulation of natural killer cell differentiation involved in immune response
growth of symbiont in host
innate immune response
defense response to Gram-positive bacterium
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