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Sequence of this protein is as follows: MAMSEWPLNN GHREDPAPGL LSEELLQDEE TLLSFMRDPS LRPGDPASKA RGRTRLPAKK KPPPPPPQDG PGSRTTPDKA PKKTWGQDAG SGKGGQGPPT RKPPRRTSSH LPSSPAAGDC PILATPESPP PLAPETPDEA ASVAADSDVQ VPGPAASPKP LGRLRPPRES KVTRRLPGAR PDAGMGPPSA VAERPKISLH FDTETDGYFS DGEMSDSDVE AEDGGVQRGP REAGAEEVVR MGVLAS
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase Jade-2; Jade family PHD finger protein 2; PHD finger protein 15
基因别名: JADE-2; JADE2; KIAA0239; PHF15
UniProt ID: (Human) Q9NQC1
Entrez Gene ID: (Human) 23338