Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-34381
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid synthetic peptide near the carboxy terminus of human PHOX2A
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551733
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-34381 can be used with blocking peptide PEP-1424.
Target Information
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: aristaless homeobox gene homolog; aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; paired mesoderm homeobox 2a; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; PHOX2A homeodomain protein
Gene Aliases: ARIX; CFEOM2; FEOM2; NCAM2; Phox2; PHOX2A; Pmx2; PMX2A
UniProt ID: (Human) O14813, (Mouse) Q62066, (Rat) Q62782
Entrez Gene ID: (Human) 401, (Mouse) 11859, (Rat) 116648
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
sequence-specific DNA binding
homeodomain transcription factor
noradrenergic neuron differentiation
transcription, DNA-templated
somatic motor neuron differentiation
oculomotor nerve formation
trochlear nerve formation
locus ceruleus development
midbrain development
regulation of respiratory gaseous exchange
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
dopaminergic neuron differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
parasympathetic nervous system development
aging
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support