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产品信息
PA5-40121
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human PHOX2B.
偶联物
形式
Liquid
浓度
1.42 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2605875
产品详细信息
Recommended positive controls: IMR32, SK-N-AS, and SH-SY5Y cells.
Predicted reactivity: Mouse (100%), Xenopus laevis (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: NBPhox; neuroblastoma paired-type homeobox protein; Neuroblastoma Phox; paired mesoderm homeobox 2b; Paired mesoderm homeobox protein 2B; Paired-like homeobox 2B; PHOX2B homeodomain protein
基因别名: NBLST2; NBPhox; PHOX2B; PMX2B
UniProt ID: (Human) Q99453
Entrez Gene ID: (Human) 8929
neuron migration
regulation of respiratory gaseous exchange by neurological system process
noradrenergic neuron differentiation
noradrenergic neuron development
brainstem development
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
glial cell differentiation
regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
cell differentiation in hindbrain
medullary reticular formation development
hindbrain tangential cell migration
skeletal muscle cell differentiation
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
autonomic nervous system development
enteric nervous system development
sympathetic nervous system development
parasympathetic nervous system development
inner ear development
efferent axon development in a lateral line nerve
respiratory system development
retrotrapezoid nucleus neuron differentiation
sympathetic ganglion development
negative regulation of cell cycle arrest
dopaminergic neuron differentiation
cellular response to BMP stimulus
neural crest cell migration involved in autonomic nervous system development
