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产品信息
PA5-89212
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_0060902)
偶联物
形式
Liquid
浓度
4.39 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805421
产品详细信息
Immunogen sequence: FMEDGSWCPM KPKKEASEVC PPPGYGLDGL QYSPVQGGDP SENKKKVEVI DLTIESSSDE EDLPPTKKHC SVTSAAIPAL PGSKGVLTSG HQPSSVLRSP AMGTLGGDFL SSLPLHEYPP AFPLGADIQG LDLFSFLQTE SQHYGPSVIT SLDEQDALGH FFQYRGTPSH FLGPLAPTLG SSHCSATPAP PPGRVSSIVA PGGALREGHG GPLPSGPSLT GCRSDIISLD
靶标信息
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.
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生物信息学
蛋白别名: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; Protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5
基因别名: PIAS3; ZMIZ5
UniProt ID: (Human) Q9Y6X2
Entrez Gene ID: (Human) 10401
