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PIKFYVE Antibody (MA5-27291) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a PIKFYVE monoclonal antibody (Product # MA5-27291) at a dilution of 1:2000.
产品信息
MA5-27291
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI1A5
抗原
Full length human recombinant protein of PIKFYVE produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2723483
靶标信息
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
基因别名: CFD; FAB1; HEL37; KIAA0981; PIKFYVE; PIP5K; PIP5K3; ZFYVE29
UniProt ID: (Human) Q9Y2I7
Entrez Gene ID: (Human) 200576
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
myelin assembly
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
retrograde transport, endosome to Golgi
phosphatidylinositol phosphorylation
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
