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Product Details
PA5-103347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PINX1(Accession Q96BK5), corresponding to amino acid residues T205-A255.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2852692
Product Specific Information
Antibody detects endogenous levels of total PINX1.
Target Information
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 67-11-3 protein; FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTS1; MGC8850; PIN2 interacting protein 1; pin2-interact; PIN2-interacting protein 1; PIN2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PIN2/TRF1-interacting protein; Protein 67-11-3; TRF1-interacting protein 1
Gene Aliases: 2210403I16Rik; 2610028A01Rik; 67-11-3; AU024023; LPTL; LPTS; LPTS1; PINX1
UniProt ID: (Human) Q96BK5, (Mouse) Q9CZX5
Entrez Gene ID: (Human) 54984, (Mouse) 72400
telomere maintenance via telomerase
mitotic metaphase plate congression
negative regulation of cell proliferation
negative regulation of protein ubiquitination
regulation of protein stability
negative regulation of telomere maintenance via telomerase
regulation of telomerase activity
negative regulation of telomerase activity
protein localization to chromosome, telomeric region
protein localization to nucleolus
negative regulation of telomere maintenance via telomere lengthening
positive regulation of telomeric DNA binding
positive regulation of protein localization to nucleolus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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