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产品信息
PA5-18009
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (SMLAERRRKQKWAV) corresponding to the N-terminus amino acids of PINX1 (aa 2-16).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10977980
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
靶标信息
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67-11-3 protein; FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; MGC8850; PIN2 interacting protein 1; pin2-interact; PIN2-interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; Protein 67-11-3; TRF1-interacting protein 1
基因别名: LPTL; LPTS; PINX1
UniProt ID: (Human) Q96BK5
Entrez Gene ID: (Human) 54984
telomere maintenance via telomerase
mitotic metaphase plate congression
negative regulation of cell proliferation
negative regulation of protein ubiquitination
regulation of protein stability
negative regulation of telomere maintenance via telomerase
regulation of telomerase activity
negative regulation of telomerase activity
protein localization to chromosome, telomeric region
protein localization to nucleolus
negative regulation of telomere maintenance via telomere lengthening
positive regulation of telomeric DNA binding
positive regulation of protein localization to nucleolus
