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产品信息
H00200576-B02P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PIP5K3 (NP_689884.1, 1 a.a. approximately 451 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.48 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL QRRSSALGDL RACTYCRKIA LSYAHSTDSN SIGEDLNALS DSACSVSVLD PSEPRTPVGS RKASRNIFLE DDLAWQSLIH PDSSNTPLST RLVSVQEDAG KSPARNRSAS ITNLSLDRSG SPMVPSYETS VSPQANRTYV RTETTEDERK ILLDSVQLKD LWKKICHHSS GMEFQDHRYW LRTHPNCIVG KELVNWLIRN GHIATRAQAI AIGQAMVDGR WLDCVSHHDQ LFRDEYALYR PLQSTEFSET PSPDSDSVNS VEGHSEPSWF KDIKFDDSDT EQIAEEGDDN LANSASPSKR TSVSSFQSTV DSDSAASISL NVELDNVNFH IKKPSKYPHV PPHPADQKGR R
靶标信息
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; epididymis luminal protein 37; FYVE finger-containing phosphoinositide kinase; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; Serine-protein kinase PIKFYVE; type III PIP kinase; zinc finger, FYVE domain containing 29
基因别名: CFD; FAB1; HEL37; KIAA0981; PIKFYVE; PIP5K; PIP5K3; ZFYVE29
UniProt ID: (Human) Q9Y2I7
Entrez Gene ID: (Human) 200576
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
myelin assembly
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
retrograde transport, endosome to Golgi
phosphatidylinositol phosphorylation
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
