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PITX2 Antibody (PA5-85551) in WB
PITX2 Polyclonal Antibody detects PITX2 protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract. B. 30 µg whole cell lysate/extract of human PITX2-transfected 293T cells.12 % SDS-PAGE. PITX2 Polyclonal Antibody (Product # PA5-85551) dilution: 1:10,000.
产品信息
PA5-85551
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human PITX2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792691
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (93%).
Positive Control: human PITX2-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: all1-responsive gene 1; ALL1-responsive protein ARP1; Homeobox protein PITX2; paired-like homeodomain 2; Paired-like homeodomain transcription factor 2; Pituitary homeobox 2; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin
基因别名: ARP1; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PITX2; PTX2; RGS; RIEG; RIEG1; RS
UniProt ID: (Human) Q99697
Entrez Gene ID: (Human) 5308
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
chromatin DNA binding
homeodomain transcription factor
patterning of blood vessels
vasculogenesis
in utero embryonic development
neuron migration
extraocular skeletal muscle development
atrioventricular valve development
cardiac neural crest cell migration involved in outflow tract morphogenesis
pulmonary myocardium development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
determination of left/right symmetry
myoblast fusion
male gonad development
female gonad development
response to hormone
Wnt signaling pathway
subthalamic nucleus development
hypothalamus cell migration
regulation of cell migration
embryonic camera-type eye development
response to vitamin A
embryonic hindlimb morphogenesis
hair cell differentiation
vascular smooth muscle cell differentiation
deltoid tuberosity development
odontogenesis of dentin-containing tooth
odontogenesis
camera-type eye development
positive regulation of DNA binding
positive regulation of transcription from RNA polymerase II promoter
spleen development
embryonic digestive tract morphogenesis
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell development
somatotropin secreting cell differentiation
prolactin secreting cell differentiation
ventricular septum morphogenesis
left lung morphogenesis
pulmonary vein morphogenesis
superior vena cava morphogenesis
endodermal digestive tract morphogenesis
iris morphogenesis
cell proliferation involved in outflow tract morphogenesis
left/right axis specification
positive regulation of myoblast proliferation
