Product References
Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.
Nature communications
Schmidt S,Luecken MD,Trümbach D,Hembach S,Niedermeier KM,Wenck N,Pflügler K,Stautner C,Böttcher A,Lickert H,Ramirez-Suastegui C,Ahmad R,Ziller MJ,Fitzgerald JC,Ruf V,van de Berg WDJ,Jonker AJ,Gasser T,Winner B,Winkler J,Vogt Weisenhorn DM,Giesert F,Theis FJ,Wurst W
38-2850 was used in Immunocytochemistry, Immunohistochemistry (Frozen) to analyze human neural precursor cells (hNPCs) from sporadic PD (sPD) patients.
Tue Aug 16 00:00:00 UTC 2022
Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
Frontiers in cell and developmental biology
Nouri P,Götz S,Rauser B,Irmler M,Peng C,Trümbach D,Kempny C,Lechermeier CG,Bryniok A,Dlugos A,Euchner E,Beckers J,Brodski C,Klümper C,Wurst W,Prakash N
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Nov 17 00:00:00 UTC 2020
Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.
Frontiers in cell and developmental biology
Nouri P,Götz S,Rauser B,Irmler M,Peng C,Trümbach D,Kempny C,Lechermeier CG,Bryniok A,Dlugos A,Euchner E,Beckers J,Brodski C,Klümper C,Wurst W,Prakash N
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Nov 17 00:00:00 UTC 2020
Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.
Stem cell reports
Kim H,Park HJ,Choi H,Chang Y,Park H,Shin J,Kim J,Lengner CJ,Lee YK,Kim J
38-2850 was used in Western Blotting to study the pathogenic mechanisms associated with Parkinson's disease-associated LRRK2 mutation.
Tue Mar 05 00:00:00 UTC 2019
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jovanovic VM,Salti A,Tilleman H,Zega K,Jukic MM,Zou H,Friedel RH,Prakash N,Blaess S,Edenhofer F,Brodski C
38-2850 was used in Immunohistochemistry-immunofluorescence to identify BMP/SMAD signalling as a novel critical pathway orchestrating essential steps of mammalian midbrain dopaminergic neurogenesis in vivo that balances progenitor proliferation and differentiation.
Wed Feb 14 00:00:00 UTC 2018
Conserved Upstream Regulatory Regions in Mammalian Tyrosine Hydroxylase.
Molecular neurobiology
Wang M,Fones L,Cave JW
38-2850 was used in ChIP Assay to provide key insights into the upstream regulatory genomic architecture and regulatory mechanisms controlling mammalian Th gene transcription.
Sat Sep 01 00:00:00 UTC 2018
A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons.
Development (Cambridge, England)
Nouri N,Awatramani R
38-2850 was used in Immunohistochemistry to identify a novel boundary subdividing the mesodiencephalic floor plate into two microdomains, defined by engrailed 1 and developing brain homeobox 1.
Wed Mar 01 00:00:00 UTC 2017
A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.
The EMBO journal
Villaescusa JC,Li B,Toledo EM,Rivetti di Val Cervo P,Yang S,Stott SR,Kaiser K,Islam S,Gyllborg D,Laguna-Goya R,Landreh M,Lönnerberg P,Falk A,Bergman T,Barker RA,Linnarsson S,Selleri L,Arenas E
38-2850 was used in Immunofluorescence in immunohistochemistry on frozen tissues to study a novel transcriptional network controlled by pre-B-cell leukaemia homeobox 1, required for midbrain dopaminergic neuron specification and survival.
Thu Sep 15 00:00:00 UTC 2016
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
Developmental biology
Gazea M,Tasouri E,Tolve M,Bosch V,Kabanova A,Gojak C,Kurtulmus B,Novikov O,Spatz J,Pereira G,Hübner W,Brodski C,Tucker KL,Blaess S
38-2850 was used in immunohistochemistry to characterize sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain by primary cilia
Fri Jan 01 00:00:00 UTC 2016
Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis.
Neurogenesis (Austin, Tex.)
Gazea M,Tasouri E,Heigl T,Bosch V,Tucker KL,Blaess S
38-2850 was used in Immunohistochemistry to define a precise spatiotemporal window within which primary cilia-dependent Sonic Hedgehog signaling determines midbrain dopaminergic fate.
Thu Oct 01 00:00:00 UTC 2020
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fukusumi Y,Meier F,Götz S,Matheus F,Irmler M,Beckervordersandforth R,Faus-Kessler T,Minina E,Rauser B,Zhang J,Arenas E,Andersson E,Niehrs C,Beckers J,Simeone A,Wurst W,Prakash N
38-2850 was used in Immunohistochemistry to show that Dickkopf 3 is necessary and sufficient for proper differentiation and survival of a rostrolateral mesodiencephalic dopaminergic neuron subset.
Wed Sep 30 00:00:00 UTC 2015
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.
Nature communications
Jiang H,Xu Z,Zhong P,Ren Y,Liang G,Schilling HA,Hu Z,Zhang Y,Wang X,Chen S,Yan Z,Feng J
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunocytochemistry
Mon Dec 07 00:00:00 UTC 2015
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Nature chemical biology
Theofilopoulos S,Wang Y,Kitambi SS,Sacchetti P,Sousa KM,Bodin K,Kirk J,Saltó C,Gustafsson M,Toledo EM,Karu K,Gustafsson JÅ,Steffensen KR,Ernfors P,Sjövall J,Griffiths WJ,Arenas E
38-2850 was used in immunocytochemistry to identify regulators of neurogenesis and neuronal survival.
Fri Feb 01 00:00:00 UTC 2013
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Stott SR,Metzakopian E,Lin W,Kaestner KH,Hen R,Ang SL
38-2850 was used in Immunohistochemistry to demonstrate a later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mesodiencephalic dopaminergic neurons.
Wed May 01 00:00:00 UTC 2013
Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease.
Neurobiology of aging
Reyes S,Fu Y,Double KL,Cottam V,Thompson LH,Kirik D,Paxinos G,Watson C,Cooper HM,Halliday GM
38-2850 was used in immunohistochemistry to determine the localization of Pitx3, Otx2, and DCC in the human brain.
Fri Mar 01 00:00:00 UTC 2013
Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse.
Neurobiology of disease
Panayotis N,Pratte M,Borges-Correia A,Ghata A,Villard L,Roux JC
38-2850 was used in immunohistochemistry - frozen section to investigate the role of Mecp2 in central dopaminergic neurons using a Rett syndrome mouse model
Tue Feb 01 00:00:00 UTC 2011
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peng C,Aron L,Klein R,Li M,Wurst W,Prakash N,Le W
Wed Sep 07 00:00:00 UTC 2011
Pitx3 is a critical mediator of GDNF-induced BDNF expression in nigrostriatal dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peng C,Aron L,Klein R,Li M,Wurst W,Prakash N,Le W
Wed Sep 07 00:00:00 UTC 2011
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yan CH,Levesque M,Claxton S,Johnson RL,Ang SL
Wed Aug 31 00:00:00 UTC 2011
Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tang M,Villaescusa JC,Luo SX,Guitarte C,Lei S,Miyamoto Y,Taketo MM,Arenas E,Huang EJ
Wed Jul 07 00:00:00 UTC 2010
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.
Nature neuroscience
Di Salvio M,Di Giovannantonio LG,Acampora D,Prosperi R,Omodei D,Prakash N,Wurst W,Simeone A
38-2850 was used in Immunohistochemistry to indicate that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP.
Wed Dec 01 00:00:00 UTC 2010
Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development.
Developmental dynamics : an official publication of the American Association of Anatomists
Li Y,Piatigorsky J
Published figure using PITX3 polyclonal antibody (Product # 38-2850) in Immunohistochemistry
Tue Sep 01 00:00:00 UTC 2009
In-vitro analysis of Pitx3 in mesodiencephalic dopaminergic neuron maturation.
The European journal of neuroscience
Papanikolaou T,Amano T,Lennington J,Sink K,Farrar AM,Salamone J,Yang X,Conover JC
38-2850 was used in Immunocytochemistry, Immunohistochemistry (Frozen) to assess the role of Pitx3 in the specification and final maturation of dopaminergic neurons by using Pitx3-deficient embryonic stem cells in an in-vitro differentiation culture system.
Mon Jun 01 00:00:00 UTC 2009
Effects on differentiation of embryonic ventral midbrain progenitors by Lmx1a, Msx1, Ngn2, and Pitx3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Roybon L,Hjalt T,Christophersen NS,Li JY,Brundin P
38-2850 was used in immunocytochemistry to elucidate how to induce controlled differentiation of neural stem cells
Wed Apr 02 00:00:00 UTC 2008
