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PITX3 Antibody (MA5-42696) in WB
Western blot analysis of PITX3 in extracts of various cell lines. Samples were incubated with PITX3 Monoclonal antibody (Product # MA5-42696) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
MA5-42696
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3P4U8
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX3 (O75364).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911837
产品详细信息
Positive test controls include: C6, SH-SY5Y, U-87MG, Mouse eye. The target is usually found in the following locations: Nucleus.
Immunogen sequence: MEFGLLSEAE ARSPALSLSD AGTPHPQLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN
靶标信息
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aphakia; Homeobox protein PITX3; homeobox protein PTX3; MGC12766; paired-like homeodomain 3; Paired-like homeodomain transcription factor 3; Pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3)
基因别名: ak; ASMD; ASOD; CTPP4; CTRCT11; PITX3; PTX3
UniProt ID: (Human) O75364, (Mouse) O35160, (Rat) P81062
Entrez Gene ID: (Human) 5309, (Mouse) 18742, (Rat) 29609
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
lens development in camera-type eye
lens morphogenesis in camera-type eye
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
locomotory behavior
organ morphogenesis
midbrain development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron development
lens fiber cell differentiation
dopaminergic neuron differentiation
transcription, DNA-templated
multicellular organism development
regulation of gene expression
