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产品信息
PA5-89331
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 260-340 of human PKC-beta (NP_9977001)
偶联物
形式
Liquid
浓度
0.61 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805498
产品详细信息
Immunogen sequence: SFGISELQKA SVDGWFKLLS QEEGEYFNVP VPPEGSEANE ELRQKFERAK ISQGTKVPEE KTTNTVSKFD NNGNRDRMKL T
Positive Samples: Mouse liver; Cellular Location: Cytoplasm, Membrane, Nucleus, Peripheral membrane protein
靶标信息
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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生物信息学
蛋白别名: PKC-B; PKC-beta; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide
基因别名: A130082F03Rik; PKC-Beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771, (Mouse) P68404, (Rat) P68403
Entrez Gene ID: (Human) 5579, (Mouse) 18751, (Rat) 25023
chromatin binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T6 specific)
histone binding
androgen receptor binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
response to hypoxia
adaptive immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
negative regulation of glucose transport
peptidyl-serine phosphorylation
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
histone H3-T6 phosphorylation
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to carbohydrate stimulus
immune system process
regulation of transcription, DNA-templated
regulation of dopamine secretion
phosphorylation
chromatin modification
regulation of growth
response to drug
response to glucose
dibenzo-p-dioxin metabolic process
response to vitamin D
positive regulation of odontogenesis of dentin-containing tooth
response to ethanol
