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产品信息
OSP00167W-100UL
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from mouse PKD1 conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: PKD1.
靶标信息
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Autosomal dominant polycystic kidney disease 1 protein homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystin 1; Polycystin-1
基因别名: mFLJ00285; PC1; Pkd1
UniProt ID: (Mouse) O08852
Entrez Gene ID: (Mouse) 18763
cartilage condensation
blood vessel development
in utero embryonic development
kidney development
liver development
embryonic placenta development
protein export from nucleus
nitrogen compound metabolic process
calcium ion transport
cell cycle arrest
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
heart development
single organismal cell-cell adhesion
peptidyl-serine phosphorylation
establishment of cell polarity
regulation of cell adhesion
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of protein binding
response to fluid shear stress
lymph vessel morphogenesis
cytoplasmic sequestering of transcription factor
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
detection of mechanical stimulus
regulation of mitotic spindle organization
placenta blood vessel development
patterning of lymph vessels
regulation of proteasomal protein catabolic process
calcium ion transmembrane transport
renal system development
cation transmembrane transport
