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PKN1 Antibody (H00005585-D01P) in WB
Western Blot analysis of PKN1 expression in transfected 293T cell line (H00005585-T01) by PKN1 MaxPab polyclonal antibody.
Lane 1: PKN1 transfected lysate(103.90 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PKN1 transfected lysate(103.90 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00005585-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PKN1 (AAH40061.1, 1 a.a. approximately 942 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL PDPAATHDGP QSPGAGGPTC SATNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSTKDR KLLLTAQQML QDSKTKIDII RMQLRRALQA GQLENQAAPD DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS AAKAPDRKAV SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG PGTPDSRPPF LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT VVGQTSWKPC GPNAWDQSFT LELERARELE LAVFWRDQRG LCALKFLKLE DFLDNERHEV QLDMEPQGCL VAEVTFRNPV IERIPRLRRQ KKIFSKQQGK AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS EARTTGDISV EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD IVARDEVESL MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG GDLMLHIHSD VFSEPRAIFY SACVVLGLQF LHEHKIVYRD LKLDNLLLDT EGYVKIADFG LCKEGMGYGD RTSTFCGTPE FLAPEVLTDT SYTRAVDWWG LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA EAIGIMRRLL RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD ISNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC
靶标信息
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PAK-1; Protease-activated kinase 1; Protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; Protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine-threonine kinase N; Serine-threonine protein kinase N; serine/threonine kinase 3; serine/threonine protein kinase N; Serine/threonine-protein kinase N1
基因别名: DBK; F730027O18Rik; PAK-1; PAK1; PKN; PKN-ALPHA; PKN1; PRK1; PRKCL1; Stk3
UniProt ID: (Human) Q16512, (Mouse) P70268
Entrez Gene ID: (Human) 5585, (Mouse) 320795
chromatin binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein kinase C binding
protein binding
ATP binding
GTP-Rho binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T11 specific)
histone binding
histone deacetylase binding
Rac GTPase binding
androgen receptor binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
B cell homeostasis
B cell apoptotic process
regulation of germinal center formation
regulation of immunoglobulin production
renal system process
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
negative regulation of protein kinase activity
hyperosmotic response
signal transduction
activation of JUN kinase activity
epithelial cell migration
peptidyl-serine phosphorylation
negative regulation of B cell proliferation
histone H3-T11 phosphorylation
spleen development
regulation of cell motility
negative regulation of protein phosphorylation
regulation of transcription, DNA-templated
phosphorylation
chromatin modification
