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产品信息
PA5-66048
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664548
产品详细信息
Immunogen sequence: NLLTERSTFTD SQLGNADMEM TLERAVSMLE ADHMLPSRIS AAATFIQHEC FQKSEARKRV NQLRGILKLL QLLKVQNEDV QRAVC
Highest antigen sequence identity to the following orthologs - mouse 78%, rat 51%.
靶标信息
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
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生物信息学
molecular_function
protein kinase C binding
protein binding
sodium channel regulator activity
intermediate filament binding
protein complex scaffold
ion channel binding
alpha-catenin binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
cadherin binding involved in cell-cell adhesion
intermediate filament binding protein
desmosome assembly
heart development
negative regulation of cell proliferation
positive regulation of sodium ion transport
gap junction assembly
single organismal cell-cell adhesion
negative regulation of cell migration
adherens junction maintenance
intermediate filament bundle assembly
maintenance of organ identity
ventricular cardiac muscle tissue morphogenesis
lipid homeostasis
cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
cell-cell signaling involved in cardiac conduction
cell communication by electrical coupling involved in cardiac conduction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
establishment of protein localization to plasma membrane
regulation of ventricular cardiac muscle cell action potential
regulation of bicellular tight junction assembly
