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产品信息
PA5-42005
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human PLA2G5
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2608856
产品详细信息
Peptide sequence: YRFAWGVVTC EPGPFCHVNL CACDRKLVYC LKRNLRSYNP QYQYFPNILC
Sequence homology: Cow: 86%; Dog: 93%; Guinea Pig: 86%; Horse: 85%; Human: 100%; Rat: 86%
靶标信息
This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+-dependent phospholipase A2; DKFZp686C2294; MGC46205; Phosphatidylcholine 2-acylhydrolase 5; Phospholipase A2 group V; phospholipase A2, group V; PLA2-10
基因别名: FRFB; GV-PLA2; hVPLA(2); PLA2-10; PLA2G5
UniProt ID: (Human) P39877
Entrez Gene ID: (Human) 5322
phospholipid metabolic process
phosphatidic acid biosynthetic process
platelet activating factor biosynthetic process
positive regulation of phospholipase activity
lipid catabolic process
leukotriene biosynthetic process
response to cytokine
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
arachidonic acid secretion
response to cAMP
positive regulation of ERK1 and ERK2 cascade
