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产品信息
PA5-113180
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2867914
靶标信息
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
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生物信息学
蛋白别名: Choline phosphatase 6; Mitochondrial cardiolipin hydrolase; Mitochondrial phospholipase; MitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; Phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family, member 6; Phospholipase D6; PLD 6; PLD6; Protein zucchini homolog
基因别名: 4933433K01Rik; Gm10; mitoPLD; mZuc; PLD6; ZUC
UniProt ID: (Human) Q8N2A8, (Mouse) Q5SWZ9
Entrez Gene ID: (Human) 201164, (Mouse) 194908
endoribonuclease activity
protein binding
cardiolipin synthase activity
cardiolipin hydrolase activity
protein homodimerization activity
metal ion binding
catalytic activity
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
phospholipase
meiotic nuclear division
spermatid development
mitochondrial fusion
positive regulation of mitochondrial fusion
lipid catabolic process
P granule organization
cardiolipin biosynthetic process
piRNA metabolic process
DNA methylation involved in gamete generation
RNA phosphodiester bond hydrolysis, endonucleolytic
lipid metabolic process
spermatogenesis
cell differentiation
meiotic cell cycle
