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Product Details
PA5-113180
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867914
Target Information
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Choline phosphatase 6; Mitochondrial cardiolipin hydrolase; Mitochondrial phospholipase; MitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; Phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family, member 6; Phospholipase D6; PLD 6; PLD6; Protein zucchini homolog
Gene Aliases: 4933433K01Rik; Gm10; mitoPLD; mZuc; PLD6; ZUC
UniProt ID: (Human) Q8N2A8, (Mouse) Q5SWZ9
Entrez Gene ID: (Human) 201164, (Mouse) 194908
endoribonuclease activity
protein binding
cardiolipin synthase activity
cardiolipin hydrolase activity
protein homodimerization activity
metal ion binding
catalytic activity
nuclease activity
endonuclease activity
hydrolase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
phospholipase
meiotic nuclear division
spermatid development
mitochondrial fusion
positive regulation of mitochondrial fusion
lipid catabolic process
P granule organization
cardiolipin biosynthetic process
piRNA metabolic process
DNA methylation involved in gamete generation
RNA phosphodiester bond hydrolysis, endonucleolytic
lipid metabolic process
spermatogenesis
cell differentiation
meiotic cell cycle
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