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PLP1 Antibody (MA5-37605) in WB
Western Blot analysis of PLP1 using the PLP1 Monoclonal Antibody (Product # MA5-37605) at a 1:1000 dilution. Lane 1: C6 whole cell lysate, Lane 2: Hela whole cell lysate, Lane 3: mouse cerebellum lysate. Lysates/proteins were loaded at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size : 30 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
产品信息
MA5-37605
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
538CT16.5.4
抗原
KLH conjugated synthetic peptide between 248-277 amino acids from the Central region of rat PIp1
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Euglobulin precipitation
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897532
靶标信息
PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Lipophilin; major myelin proteolipid protein; Myelin proteolipid protein; PLP; proteolipid; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
基因别名: GPM6C; HLD1; MMPL; PLP; PLP/DM20; PLP1; PMD; SPG2
UniProt ID: (Human) P60201, (Rat) P60203
Entrez Gene ID: (Human) 5354, (Rat) 24943
inflammatory response
integrin-mediated signaling pathway
chemical synaptic transmission
axon ensheathment
positive regulation of gene expression
astrocyte development
substantia nigra development
central nervous system myelination
long-chain fatty acid biosynthetic process
cell maturation
axon development
glial cell differentiation
myelination
