Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 4
PLSCR1 Antibody (H00005359-D01P) in WB
Western Blot analysis of PLSCR1 expression in transfected 293T cell line (H00005359-T01) by PLSCR1 MaxPab polyclonal antibody.
Lane 1: PLSCR1 transfected lysate(35.00 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PLSCR1 transfected lysate(35.00 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00005359-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PLSCR1 (NP_066928.1, 1 a.a. approximately 318 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVKMK AVMIGACFLI DFMFFESTGS QEQKSGVW
靶标信息
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; Mg(2+)-dependent nuclease; MmTRA1b; NOR1; Phospholipid scramblase 1; PL scramblase 1; Transplantability-associated protein 1
基因别名: MmTRA1a; MMTRA1B; Nor1; PLSCR1; Tra1; Tra1a; Tra1b; Tras1; Tras2
UniProt ID: (Human) O15162, (Mouse) Q9JJ00
Entrez Gene ID: (Human) 5359, (Mouse) 22038
transcription from RNA polymerase II promoter
phosphatidylserine biosynthetic process
apoptotic process
acute-phase response
positive regulation of gene expression
phospholipid scrambling
platelet activation
regulation of mast cell activation
response to interferon-beta
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of Fc receptor mediated stimulatory signaling pathway
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
immune response
phospholipid transport
myeloid cell differentiation
negative regulation of protein binding
response to interferon-alpha
positive regulation of apoptotic process
phosphatidylserine exposure on apoptotic cell surface
intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
