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PLXNA3 Antibody (PA5-47571) in IHC (P)
Immunohistochemical analysis of PLXNA3 in immersion fixed paraffin-embedded sections of rat brain (cortex). Samples were incubated with PLXNA3 polyclonal antibody (Product # PA5-47571) using a dilution of 10 µg/mL for 1 hour at room temperature followed by Anti-Goat IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using A... View More
产品信息
PA5-47571
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse Plexin A3 Leu34-Asp150
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2608296
产品详细信息
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse (rm) Plexin A1, rmPlexin A2, recombinant human (rh) Plexin B1, rhPlexin C1, and rhPlexin D1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: plexin 3; Plexin 4, SEX, homolog to the cMet/HGF receptors; Plexin-A3; SEXPLEXIN-A3
基因别名: mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4; Plxna3; SEX
UniProt ID: (Mouse) P70208, (Rat) D3ZPX4
Entrez Gene ID: (Mouse) 18846, (Rat) 309280
signal transduction
axon guidance
facial nerve structural organization
trigeminal nerve structural organization
hippocampus development
branchiomotor neuron axon guidance
pyramidal neuron development
negative regulation of axon extension involved in axon guidance
negative chemotaxis
positive regulation of cytoskeleton organization
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway
