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PLXNA3 Antibody (PA5-47571) in IHC (P)
Immunohistochemical analysis of PLXNA3 in immersion fixed paraffin-embedded sections of rat brain (cortex). Samples were incubated with PLXNA3 polyclonal antibody (Product # PA5-47571) using a dilution of 10 µg/mL for 1 hour at room temperature followed by Anti-Goat IgG VisUCyte™ HRP Polymer Antibody. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using A... View More
Product Details
PA5-47571
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse Plexin A3 Leu34-Asp150
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608296
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse (rm) Plexin A1, rmPlexin A2, recombinant human (rh) Plexin B1, rhPlexin C1, and rhPlexin D1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: plexin 3; Plexin 4, SEX, homolog to the cMet/HGF receptors; Plexin-A3; SEXPLEXIN-A3
Gene Aliases: mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4; Plxna3; SEX
UniProt ID: (Mouse) P70208, (Rat) D3ZPX4
Entrez Gene ID: (Mouse) 18846, (Rat) 309280
signal transduction
axon guidance
facial nerve structural organization
trigeminal nerve structural organization
hippocampus development
branchiomotor neuron axon guidance
pyramidal neuron development
negative regulation of axon extension involved in axon guidance
negative chemotaxis
positive regulation of cytoskeleton organization
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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