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PLZF Antibody (PA5-29213) in ICC/IF
PLZF Polyclonal Antibody detects PLZF protein at nucleus by immunofluorescent analysis. Sample: U87-MG cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PLZF protein stained by PLZF Polyclonal Antibody (Product # PA5-29213) diluted at 1:2,000. Blue: Hoechst 33342 staining.
产品信息
PA5-29213
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human,
Mouse,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 11 and 277 of Human PLZF
偶联物
形式
Liquid
浓度
1.03 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546689
产品详细信息
Recommended positive controls: K562, THP-1.
Predicted reactivity: Mouse (97%), Rat (96%), Chicken (85%), Rhesus Monkey (98%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: promyelocytic leukaemia zinc finger; Promyelocytic leukemia zinc finger protein; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); Zinc finger protein PLZF
基因别名: PLZF; ZBTB16; ZNF145
UniProt ID: (Human) Q05516
Entrez Gene ID: (Human) 7704
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
protein binding
protein C-terminus binding
protein domain specific binding
identical protein binding
protein homodimerization activity
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
mesonephros development
transcription, DNA-templated
apoptotic process
central nervous system development
negative regulation of cell proliferation
embryonic pattern specification
anterior/posterior pattern specification
protein ubiquitination
hemopoiesis
myeloid cell differentiation
positive regulation of chondrocyte differentiation
protein localization to nucleus
embryonic hindlimb morphogenesis
forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
male germ-line stem cell asymmetric division
positive regulation of NK T cell differentiation
cartilage development
positive regulation of cartilage development
