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POLD1 Antibody (PA5-34678) in IHC (P)
POLD1 Polyclonal Antibody detects DNA polymerase delta protein at cytoplasm and nucleus on human lung adenocarcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human lung adenocarcinoma. POLD1 Polyclonal Antibody (Product # PA5-34678) diluted at 1:250. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-34678
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 685 and 1071 of DNA pol delta cat (Uniprot ID#P28340)
偶联物
形式
Liquid
浓度
0.56 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2552030
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2, Molt-4, Rat2.
Predicted reactivity: Mouse (92%), Rat (91%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3'-5' exodeoxyribonuclease; CDC2 homolog; DNA polymerase delta catalytic subunit; DNA polymerase delta, catalytic subunit; DNA polymerase subunit delta p125; DNA-directed DNA polymerase delta 1; POL D; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; polymerase (DNA) delta 1, catalytic subunit; Polymerase D
基因别名: CDC2; CRCS10; MDPL; POLD; POLD1
UniProt ID: (Human) P28340, (Rat) O54747
Entrez Gene ID: (Human) 5424, (Rat) 59294
telomere maintenance via recombination
telomere maintenance
DNA synthesis involved in DNA repair
DNA replication
DNA strand elongation involved in DNA replication
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair, gap-filling
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, DNA gap filling
mismatch repair
response to UV
translesion synthesis
nucleotide-excision repair, DNA incision
cellular response to UV
DNA damage response, detection of DNA damage
DNA replication proofreading
fatty acid homeostasis
DNA catabolic process, exonucleolytic
DNA-dependent DNA replication
DNA biosynthetic process
nucleic acid phosphodiester bond hydrolysis
