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POLR1C Antibody (PA5-102312) in IHC (P)
Immunohistochemistry analysis of POLR1C in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with POLR1C polyclonal antibody (Product # PA5-102312) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102312
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human POLR1C, corresponding to a region within C-terminal amino acids.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851721
产品详细信息
Antibody detects endogenous levels of total POLR1C.
靶标信息
RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis. RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA. Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, which suggests that multiple signaling pathways are involved in carrying out Pol I transcription. RPA16, RPA40 and RPA135 are subunits of Pol I that associate with each other at an early stage of RNA Pol I assembly. RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AC40; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I and III 40 kDa polypeptide; DNA-directed RNA polymerases I and III subunit RPAC1; polymerase (RNA) I polypeptide C; polymerase (RNA) I polypeptide C, 30kDa; polymerase (RNA) I subunit C; RNA polymerase 1-1; RNA polymerase 1-1 (40 kDa subunit); RNA polymerase I subunit; RNA polymerases I and III subunit AC1; RPA39; RPA40; RPC40
基因别名: 40kDa; AA409007; AA959927; Ac2-127; AC40; AL024089; HLD11; POLR1C; POLR1E; RPA39; RPA40; RPA5; RPAC1; RPC40; Rpo1-1; TCS3
UniProt ID: (Human) O15160, (Mouse) P52432
Entrez Gene ID: (Human) 9533, (Rat) 301246, (Mouse) 20016
transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase III promoter
positive regulation of type I interferon production
positive regulation of gene expression, epigenetic
biological_process
transcription, DNA-templated
