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Invitrogen
POLR2E Monoclonal Antibody (OTI3B5)
Product Details
MA5-25454
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3B5
Immunogen
Full length human recombinant protein of POLR2E produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725060
Target Information
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA directed RNA polymerase II 23 kda polypeptide; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; DNA-directed RNA polymerase subunit RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; polymerase (RNA) II subunit E; RNA polymerase II subunit E; RNA polymerases I, II, and III subunit ABC1; RPB5 homolog; XAP4
Gene Aliases: 2410021N14Rik; 25kDa; AW208866; hRPB25; hsRPB5; POLR2E; RPABC1; RPB5; XAP4
UniProt ID: (Human) P19388, (Mouse) Q80UW8, (Rat) B0BNE2
Entrez Gene ID: (Dog) 611859, (Human) 5434, (Mouse) 66420, (Rat) 690966
mRNA splicing, via spliceosome
transcription-coupled nucleotide-excision repair
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
transcription from RNA polymerase III promoter
fibroblast growth factor receptor signaling pathway
gene expression
viral process
gene silencing by RNA
positive regulation of type I interferon production
somatic stem cell population maintenance
snRNA transcription from RNA polymerase II promoter
positive regulation of gene expression, epigenetic
positive regulation of viral transcription
transcription, DNA-templated
transcription from RNA polymerase I promoter
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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