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Product Details
PA5-31544
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 87 and 379 of Human POT1
Conjugate
Form
Liquid
Concentration
0.73 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2549017
Product Specific Information
Recommended positive controls: 293T, A431, Jurkat.
Predicted reactivity: Pig (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586D211; hPot1; POT 1; POT-1; POT1-like telomere end-binding protein; protection of telomeres 1 homolog; Protection of telomeres protein 1
Gene Aliases: CMM10; GLM9; HPOT1; POT1
UniProt ID: (Human) Q9NUX5
Entrez Gene ID: (Human) 25913
telomere maintenance via telomerase
telomere capping
telomere assembly
positive regulation of telomere maintenance via telomerase
DNA duplex unwinding
positive regulation of helicase activity
positive regulation of telomerase activity
negative regulation of telomerase activity
positive regulation of DNA strand elongation
establishment of protein localization to telomere
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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