Invitrogen

PP2A alpha/beta Recombinant Rabbit Monoclonal Antibody (SN70-08)

查看其他9个PP2A alpha/beta抗体
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说明书
实验方案
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产品信息

MA5-32304

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:200
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat, Zebrafish

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SN70-08

抗原

Recombinant protein within Human PP2A alpha + beta aa 260-309
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2809586

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: PP2A-alpha; PP2A-beta; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic alpha subunit; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase 2A, catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; protein phosphatase-2A-alpha; protein phosphatase-2A-beta; Replication protein C; RP C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146

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基因别名: AI115466; D8Ertd766e; fb17h07; fc05c02; fk24a01; PP2A; Pp2a1; Pp2a2; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; R75353; RP-C; wu:fb17h07; wu:fc05c02; wu:fk24a01; zgc:110641; zgc:55808; zgc:77172

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UniProt ID: (Human) P67775, (Human) P62714, (Mouse) P63330, (Rat) P63331, (Rat) P62716, (Mouse) P62715

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Entrez Gene ID: (Human) 5515, (Human) 5516, (Mouse) 19052, (Rat) 24672, (Rat) 24673, (Mouse) 19053, (Zebrafish) 550585, (Zebrafish) 406582

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功能
phosphoprotein phosphatase activity protein binding protein C-terminus binding metal ion binding GABA receptor binding protein serine/threonine phosphatase activity hydrolase activity enzyme binding protein kinase binding protein phosphatase binding protein domain specific binding protein complex binding protein kinase B binding ion channel binding protein dimerization activity tau protein binding protein phosphatase 2A binding protein antigen binding protein heterodimerization activity protein phosphatase
参与通路
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay inactivation of MAPK activity regulation of DNA replication regulation of transcription, DNA-templated protein dephosphorylation ceramide metabolic process apoptotic process mitotic nuclear envelope reassembly mesoderm development RNA splicing response to organic substance negative regulation of epithelial to mesenchymal transition second-messenger-mediated signaling regulation of Wnt signaling pathway regulation of cell adhesion negative regulation of cell growth regulation of growth negative regulation of tyrosine phosphorylation of Stat3 protein regulation of cell differentiation meiotic cell cycle positive regulation of protein serine/threonine kinase activity apoptotic mitochondrial changes regulation of gene expression response to endoplasmic reticulum stress response to hydrogen peroxide proteasome-mediated ubiquitin-dependent protein catabolic process response to antibiotic negative regulation of transcription from RNA polymerase II promoter regulation of protein phosphorylation negative regulation of protein phosphorylation regulation of receptor activity regulation of protein autophosphorylation positive regulation of protein phosphatase type 2A activity positive regulation of protein dephosphorylation regulation of protein catabolic process negative regulation of transcription factor import into nucleus positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cell cycle protein heterotrimerization cellular response to glucose stimulus negative regulation of calcium ion transmembrane transporter activity cardiac ventricle development heart development cellular response to insulin stimulus cellular response to calcium ion cellular response to cytokine stimulus cellular response to ethanol cellular response to follicle-stimulating hormone stimulus cellular response to steroid hormone stimulus negative regulation of Ras protein signal transduction
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