Invitrogen

PP2CA/PP2CB Polyclonal Antibody

产品信息

PA1-12396

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

0.08% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2237595

靶标信息

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ42306; IA; MGC9201; Mpp alpha; PP2C-alpha; PP2C-beta; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A, magnesium dependent, alpha isoform; Protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; protein phosphatase 1B, magnesium dependent, beta isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; Protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform; protein phosphatase, Mg2+/Mn2+ dependent, 1A; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform

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基因别名: 2310003C21Rik; 2900017D14Rik; AI427932; AU017636; BOS_11012; BOS_11461; MMPa-2; MPPa-1; PP2C-ALPHA; PP2C-beta; PP2C-beta-X; Pp2c1; Pp2c2; PP2CA; PP2Calpha; PP2CB; PP2CBETA; PPC2BETAX; PPM1A; PPM1B; PPPM1A; Pppm1b