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产品信息
PA5-42116
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human PPAP2A
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2610474
产品详细信息
Peptide sequence: DPDWSKINCS DGYIEYYICR GNAERVKEGR LSFYSGHSSF SMYCMLFVAL
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
靶标信息
Phosphatidic acid phosphatase type 2 (PAP2) was originally identified as a plasma membrane enzyme that catalyses the dephosphorylation of the putative second messenger, phosphatidic acid (PA) to diacylglycerol (DG). Subsequently, multiple isoforms of PAP2 were cloned [2-5]. It was found that these enzymes dephosphorylate a number of lipid phosphates in vitro other than PA, including the potent bioactive lipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Therefore, they have been renamed lipid phosphate phosphatases (LPPs). Currently, there are four members of this family called LPP1, LPP1a, LPP2 and LPP3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 35 kDa PAP; Hic53; hydrogen peroxide inducible protein 53; Hydrogen peroxide-inducible protein 53; Lipid phosphate phosphohydrolase 1; lipid phosphate phosphohydrolase 1a; mPAP; PAP-2a; PAP2-alpha; PAP2alpha2; PAPalpha1; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; phosphatidic acid phosphatase type 2A; phosphatidic acid phosphohydrolase type 2a; Phospholipid phosphatase 1; type-2 phosphatidic acid phosphatase alpha
基因别名: Hic53; Hpic53; LLP1a; LPP-1; LPP1; mPAP; PAP-2a; PAP2; PAP2-alpha; PAP2a; PLPP1; PPAP2A
UniProt ID: (Human) O14494, (Mouse) Q61469
Entrez Gene ID: (Human) 8611, (Mouse) 19012
protein dephosphorylation
lipid metabolic process
phospholipid metabolic process
protein kinase C-activating G-protein coupled receptor signaling pathway
negative regulation of cell proliferation
germ cell migration
regulation of lipid metabolic process
sphingolipid biosynthetic process
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
phospholipid dephosphorylation
diacylglycerol biosynthetic process
sphingosine metabolic process
ceramide metabolic process
signal transduction
dephosphorylation
