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产品信息
H00005469-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2A2
抗原
PPARBP (NP_004765, 1391 a.a. approximately 1490 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.37 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: KIIISKHDGG SPSIKAKVTL QKPGESSGEG LRPQMASSKN YGSPLISGST PKHERGSPSH SKSPAYTPQN LDSESESGSS IAEKSYQNSP SSDDGIRPLP
靶标信息
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Mediator of RNA polymerase II transcription subunit 1; p53 regulatory protein RB18A; PBP; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARG binding protein; PPRB; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TR-interacting protein 2; Trap220; TRIP-2; vitamin D receptor-interacting protein 230 kD; Vitamin D receptor-interacting protein complex component DRIP205
基因别名: ARC205; CRSP1; CRSP200; DRIP205; DRIP230; MED1; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
UniProt ID: (Human) Q15648
Entrez Gene ID: (Human) 5469
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription cofactor activity
chromatin binding
transcription cofactor activity
transcription coactivator activity
receptor activity
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
thyroid hormone receptor coactivator activity
chromatin DNA binding
nuclear hormone receptor binding
mediator complex binding
vitamin D receptor binding
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
LBD domain binding
ubiquitin protein ligase activity
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
angiogenesis
liver development
embryonic placenta development
lens development in camera-type eye
thyroid hormone mediated signaling pathway
ventricular trabecula myocardium morphogenesis
retinal pigment epithelium development
regulation of transcription from RNA polymerase I promoter
transcription initiation from RNA polymerase II promoter
thyroid hormone generation
androgen biosynthetic process
brain development
lactation
positive regulation of gene expression
negative regulation of keratinocyte proliferation
protein ubiquitination
keratinocyte differentiation
monocyte differentiation
intracellular steroid hormone receptor signaling pathway
androgen receptor signaling pathway
organ regeneration
positive regulation of intracellular estrogen receptor signaling pathway
positive regulation of protein import into nucleus, translocation
positive regulation of mammary gland epithelial cell proliferation
embryonic heart tube development
embryonic hindlimb morphogenesis
embryonic hemopoiesis
peroxisome proliferator activated receptor signaling pathway
cellular response to hepatocyte growth factor stimulus
megakaryocyte development
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
cellular lipid metabolic process
fat cell differentiation
positive regulation of keratinocyte differentiation
positive regulation of erythrocyte differentiation
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
erythrocyte development
enucleate erythrocyte development
regulation of cell cycle
positive regulation of interferon-gamma-mediated signaling pathway
mammary gland branching involved in thelarche
mammary gland branching involved in pregnancy
epithelial cell proliferation involved in mammary gland duct elongation
positive regulation of G0 to G1 transition
ERK1 and ERK2 cascade
regulation of vitamin D receptor signaling pathway
cellular response to epidermal growth factor stimulus
cellular response to steroid hormone stimulus
cellular response to thyroid hormone stimulus
positive regulation of receptor activity
positive regulation of hepatocyte proliferation
regulation of RNA biosynthetic process
