Invitrogen

PPCDC Polyclonal Antibody

PPCDC Antibody in Immunocytochemistry (ICC/IF)

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PPCDC Antibody (PA5-61065) in ICC/IF

Immunofluorescent staining of PPCDC in human cell line A549 using a PPCDC Polyclonal Antibody (Product # PA5-61065) shows localization to cytosol.

PPCDC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-61065

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:50

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human PPCDC. Recombinant protein control fragment (Product #RP-98087).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2645806

产品详细信息

Immunogen sequence: LLVAPLDANT LGKVASGICD NLLTCVMRAW DRSKPLLFCP AMNTAMWEHP ITAQQVDQLK AFGYVEIPCV AKKLVCGDEG LGAMAEVGTI V

Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.

靶标信息

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC, one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathy.

Journal of inherited metabolic disease

Bravo-Alonso I,Morin M,Arribas-Carreira L,Álvarez M,Pedrón-Giner C,Soletto L,Santolaria C,Ramón-Maiques S,Ugarte M,Rodríguez-Pombo P,Ariño J,Moreno-Pelayo MÁ,Pérez B

PA5-61065 was used in Western Blot to describe a new, ultra-rare, severe inborn error of metabolism due to pathogenic variants of phosphopantothenoylcysteine decarboxylase.