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Immunogen sequence: KKPPLLDRPG EGSYNRYYSH VDYRDYDEGR SFSHDRRSGP PHRGDESGYR WTRDDHSASR QPEYRDMRDG FRRKSFYSSH YARERSPYKR DNTFFRESPV GRKDSPHSR
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDC7 expression repressor; CR; Gastric cancer antigen Ga50; MGC48786; Periphilin-1
基因别名: CR; HSPC206; HSPC232; PPHLN1
UniProt ID: (Human) Q8NEY8
Entrez Gene ID: (Human) 51535