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产品信息
MA5-25536
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI3E10
抗原
Full length human recombinant protein of PPM1B produced in HEK293T cell
偶联物
形式
Liquid
浓度
0.42 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2725087
靶标信息
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PP2C-beta; Protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform
基因别名: PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX; PPM1B
UniProt ID: (Human) O75688
Entrez Gene ID: (Human) 5495
protein dephosphorylation
N-terminal protein myristoylation
negative regulation of interferon-beta production
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of defense response to virus
