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PPM1F Antibody (PA5-15571) in IHC (P)
Immunohistochemistry analysis of PPM1F in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with PPM1F polyclonal antibody (Product # PA5-15571) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
产品信息
PA5-15571
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human PPM1F
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2169927
靶标信息
PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; hFem-2; Partner of PIX 2; partner of PIX2; PP2C phosphatase; Protein fem-2 homolog; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase, Mg2+/Mn2+ dependent, 1F
基因别名: 1110021B16Rik; 4933427B07Rik; CAMKP; CaMKPase; FEM-2; hFEM-2; KIAA0015; mKIAA0015; POPX2; PPM1F
UniProt ID: (Human) P49593, (Mouse) Q8CGA0
Entrez Gene ID: (Human) 9647, (Mouse) 68606
negative regulation of protein kinase activity
positive regulation of gene expression
positive regulation of epithelial cell migration
positive regulation of cell-substrate adhesion
histone dephosphorylation
negative regulation of peptidyl-serine phosphorylation
cellular response to drug
peptidyl-threonine dephosphorylation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of protein kinase activity by regulation of protein phosphorylation
negative regulation of transcription, DNA-templated
positive regulation of growth
positive regulation of chemotaxis
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
intrinsic apoptotic signaling pathway
protein dephosphorylation
apoptotic process
