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产品信息
PA5-83053
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790209
产品详细信息
Immunogen sequence: DCTQQYKAEK QKGRFRMKER EEMWQKIEEL ARLNPQYPMF RAPPPLPPVY SMETETPTAE DIQLLKRTVE TEAVQMLKDI KKEKVLLRRK SELPQDVY
靶标信息
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2 beta (transformer-2 beta) transcripts and is thought to interfere with constitutive 5'-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
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生物信息学
蛋白别名: MGC2134; MGC8949; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PP2CB; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; testis expressed gene 271
基因别名: B'delta; B56D; MRD35; PPP2R5D; TEG-271; Tex271
UniProt ID: (Human) Q14738
Entrez Gene ID: (Human) 5528, (Rat) 363193, (Mouse) 21770
protein dephosphorylation
signal transduction
nervous system development
regulation of protein phosphatase type 2A activity
regulation of protein phosphorylation
positive regulation of neuron projection development
regulation of protein autophosphorylation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of neurotrophin TRK receptor signaling pathway
cellular response to growth factor stimulus
