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PPT1 Antibody (MA5-26457) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human prostate tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a PPT1 monoclonal antibody (Product # MA5-26457).
Product Details
MA5-26457
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1A10
Immunogen
Human recombinant protein fragment corresponding to amino acids 100-306 of PPT1 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723508
Target Information
The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3.1.2.22; ceroid-palmitoyl-palmitoyl-protein thioesterase 1; Palmitoyl-protein hydrolase 1; Palmitoyl-protein thioesterase 1; palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile); PPT-1
Gene Aliases: CLN1; INCL; PPT; PPT1
UniProt ID: (Human) P50897
Entrez Gene ID: (Human) 5538, (Dog) 475316
protein depalmitoylation
receptor-mediated endocytosis
pinocytosis
lysosomal lumen acidification
chemical synaptic transmission
neurotransmitter secretion
nervous system development
brain development
visual perception
grooming behavior
associative learning
adult locomotory behavior
protein transport
lipid catabolic process
sphingolipid catabolic process
protein catabolic process
negative regulation of cell growth
membrane raft organization
regulation of phospholipase A2 activity
long-chain fatty-acyl-CoA biosynthetic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cellular protein catabolic process
positive regulation of receptor-mediated endocytosis
positive regulation of pinocytosis
neuron development
regulation of synapse structure or activity
response to stimulus
cofactor transport
cofactor metabolic process
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