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PRDM2 Antibody (PA5-115792) in IHC (P)
Immunohistochemistry analysis of PRDM2 in mouse colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115792) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115792
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRDM2(Accession Q13029), corresponding to amino acid residues W139-Q189.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900427
产品详细信息
Antibody detects endogenous levels of total PRDM2.
靶标信息
PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTBzf; MTE-binding protein; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; retinoblastoma interacting zinc finger protein; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RP5-1177E19.1; Zinc finger protein RIZ; zinc-finger DNA-binding protein
基因别名: 4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; HUMHOXY1; KMT8; MTB-ZF; PRDM2; RIZ; RIZ1; RIZ2; Znfpr1c1
UniProt ID: (Human) Q13029, (Rat) Q63755
Entrez Gene ID: (Human) 7799, (Mouse) 110593, (Rat) 313678
